 Key Publications - 2009Optimization of Topical Photodynamic Therapy with 3,7-bis(di-n-butylamino)Phenothiazin-5-ium Bromide for Cutaneous Leishmaniasis. OE Akilov, W Yousaf, SX Lukjan, S Verma & T Hasan. Lasers in Surgery and Medicine, 41:358-365 (2009) Work with Photopharmica’s photosensitisers at Harvard Medical School is ongoing. After optimisation of the treatment regime in a L. major infected mouse model, a single PDT treatment with PPA904 can result in the reduction of parasitic load by just under 2 logs. In animals which receive 3 PDT treatments at 4 day intervals, over 5 logs of parasitic cell kill is achieved. This article concludes that PDT with PPA904 is a promising treatment for cutaneous leishmaniasis and a clinical study would be the next step. Photodynamic Therapy and Cancer, S.B. Brown, S. Ibbotson, British Medical Journal, 1st July 2009 Professor Stan Brown, along with Dr Sally Ibbotson, Consultant Dermatologist from Dundee, published an editorial on PDT in the British Medical Journal on 1st July 2009. Entitled 'Photodynamic Therapy and Cancer', the article explains the potential of PDT in internal cancers, but emphasises the need for development of new drugs which are more 'fit for purpose' than those currently available. The article especially highlights the success of topical PDT in dermatology, especially for non-melanoma skin cancers, where more than 150 centres in the UK and Ireland offer PDT as an attractive alternative to surgery or cryotherapy. |
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